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RNA Modifications Shape Hematopoietic Stem Cell Aging: Beyond the Code.

Inge van der WerfJenna SneiferCatriona Jamieson
Published in: FEBS letters (2024)
Hematopoietic system aging is characterized by both hematopoietic stem cell (HSC) and niche degeneration resulting in myeloid lineage-biased differentiation, reduced B cell and T cell lymphopoiesis, increased HSC mobilization, and fat deposition in the bone marrow. Both alterations in RNA splicing and editing during HSC aging contribute to increased myeloid lineage skewing and inflammation-responsive transcription factors, underscoring the importance of epitranscriptomic mechanisms in the acquisition of an age-related phenotype.
Keyphrases
  • hematopoietic stem cell
  • bone marrow
  • mesenchymal stem cells
  • transcription factor
  • crispr cas
  • dendritic cells
  • oxidative stress
  • acute myeloid leukemia
  • adipose tissue
  • nucleic acid
  • immune response