A novel machine learning-based approach for the computational functional assessment of pharmacogenomic variants.

Maria-Theodora PandiMaria KorominaIordanis TsafaridisSotirios PatsilinakosEvangelos ChristoforouPeter J van der SpekGeorge P Patrinos

Published in: Human genomics (2021)

Overall, the proposed RF-based classification model holds promise to lead to an extremely useful variant prioritization and act as a scoring tool with interesting clinical applications in the fields of pharmacogenomics and personalized medicine.

Keyphrases

machine learning
big data
clinical decision support
artificial intelligence
deep learning
copy number
adverse drug
gene expression
emergency department
electronic health record
drug induced