PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.

Xinyuan ZhaoDalong ShuWenjuan SunShanshan SiWei RanBing GuoLi Cui

Published in: Cancer communications (London, England) (2022)

Collectively, these findings uncover a previously unknown molecular basis of PLEK2-enhanced c-Myc signaling in HNSCC, suggesting that PLEK2 may represent a promising therapeutic target for treating HNSCC.

Keyphrases

papillary thyroid
stem cells
squamous cell
epithelial mesenchymal transition
transcription factor
squamous cell carcinoma
childhood cancer
young adults