Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution.

Sergi Casadó-Llombart Tarek Ajami Marta Consuegra-Fernández Esther CarrerasFernando ArandaNoelia ArmigerAntonio Alcaraz Lourdes Mengual Francisco Lozano

Published in: The Prostate (2022)

The results show the impact on PCa aggressiveness and recurrence brought about by gene variants involved in modulation of lymphocyte activation (CD5, CD6) and immune-epithelial cell adhesion (CD166/ALCAM) in PCa aggressiveness and recurrence, thus supporting a role for host immune response in PCa pathophysiology.

Keyphrases

cell adhesion
copy number
prostate cancer
immune response
genome wide
genome wide identification
radical prostatectomy
free survival
gene expression
dendritic cells
toll like receptor
inflammatory response