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Comprehensive evaluation of cytomorphologic, histologic, and molecular features of DICER1-altered thyroid lesions on FNA: A multipractice experience.

Krisztina LengyelDaniel J LubinWen-Yu HsiaoSam SirotnikovGuangju LuoJames W RobertsQiuying ShiKelly MaglioccaMelinda M LewisDonald L SearsGhulam IlyasBeverly B RogersKartik Viswanathan
Published in: Cancer cytopathology (2024)
DICER1-altered thyroid lesions occurred frequently in young females and FNAs show RAS-like cytomorphology including crowded, mixed macro-/microfollicular pattern, and bland nuclear features. On resection, DICER1-altered thyroid lesions include benign (50%), low-risk lesions (30%), or high-risk malignancies (20%).
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