Insulin increases adipose adiponectin in pregnancy by inhibiting ubiquitination and degradation: Impact of obesity.

Irving L M H AyeFredrick J RosarioAnita KramerOddrun KristiansenTrond M MichelsenTheresa L PowellThomas Jansson

Published in: The Journal of clinical endocrinology and metabolism (2021)

We have identified adiponectin ubiquitination as a key mechanism by which obesity diminishes adiponectin secretion in pregnancy. This information will help us better understand the mechanisms controlling maternal insulin resistance and fetal growth in pregnancy and may provide a foundation for the development of strategies aimed at improving adiponectin production in pregnant women with obesity or gestational diabetes.

Keyphrases

insulin resistance
metabolic syndrome
pregnancy outcomes
type diabetes
high fat diet induced
adipose tissue
high fat diet
skeletal muscle
polycystic ovary syndrome
preterm birth
pregnant women
glycemic control
healthcare
weight loss
body mass index
social media