Rapid and Complete Surface Modification with Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ).

Rickdeb SenJorge EscorihuelaFloris van DelftHan Zuilhof

Published in: Angewandte Chemie (International ed. in English) (2017)

Strain-promoted oxidation-controlled cyclooctyne-1,2-quinone cycloaddition (SPOCQ) between functionalized bicyclo[6.1.0]non-4-yne (BCN) and surface-bound quinones revealed an unprecedented 100 % conjugation efficiency. In addition, monitoring by direct analysis in real time mass spectrometry (DART-MS) revealed the underlying kinetics and activation parameters of this immobilization process in dependence on its microenvironment.

Keyphrases

mass spectrometry
hydrogen peroxide
single cell
liquid chromatography
stem cells
multiple sclerosis
high resolution
high performance liquid chromatography
gas chromatography
capillary electrophoresis
quantum dots
nitric oxide
visible light