Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET.
Renaud La JoieAdrienne V VisaniOrit H Lesman-SegevSuzanne L BakerLauren EdwardsLeonardo IaccarinoDavid N Soleimani-MeigooniTaylor MellingerMustafa JanabiZachary A MillerDavid C PerryJulie PhamAmelia StromMaria Luisa Gorno-TempiniHoward J RosenBruce L MillerWilliam J JagustGil D RabinoviciPublished in: Neurology (2020)
Clinical phenotypes are associated with differential patterns of tau but not amyloid pathology. Older age and APOE4 are not only risk factors for AD but also seem to affect disease expression by promoting a more medial temporal lobe-predominant pattern of tau pathology.