Phenotypic and Genomic Characterization of Virulence Heterogeneity in Multidrug-Resistant ST11 Klebsiella pneumoniae During Inter-Host Transmission and Evolution.
Chao LiuPengcheng DuJiankang ZhaoBinbin LiChunlei WangLingxiao SunBinghuai LuYimin WangYingmei LiuBin CaoPublished in: Infection and drug resistance (2020)
During inter-host evolution and transmission, various virulence clusters of the epidemic clone, MDR-ST11, converged, conferring phenotypic virulence heterogeneity and spread within the hospital and possibly the community. Mobile/conjugative genetic elements associated with virulence-encoding gene clusters might emerge and have been transmitted within the hospital, suggesting that enhanced ongoing surveillance is essential.
Keyphrases
- multidrug resistant
- escherichia coli
- klebsiella pneumoniae
- pseudomonas aeruginosa
- staphylococcus aureus
- biofilm formation
- antimicrobial resistance
- drug resistant
- acinetobacter baumannii
- healthcare
- gram negative
- copy number
- genome wide
- single cell
- cystic fibrosis
- public health
- mental health
- adverse drug
- gene expression
- dna methylation
- drug induced
- electronic health record
- wastewater treatment