A single-molecular ruthenium(II) complex-based NIR-II fluorophore for enhanced chemo-photothermal therapy.

Qianqian LiYishen LiuBingshan ZhaoJiapeng LeiSiyu LuWanxia GongKe LiangJunzhu WuXuechuan Hong Yuling Xiao

Published in: Chemical communications (Cambridge, England) (2022)

Novel NIR-II Ru(II) polypyridyl fluorophore Ru-1 dots for synergistic chemo-photothermal therapy against 4T1 tumors were designed and synthesized. Guided by in vivo NIR-II fluorescence imaging, the synergistic therapeutic efficacy, intracellular delivery, and biodistribution of the Ru-1 dots were precisely tracked in real-time.

Keyphrases

fluorescence imaging
photodynamic therapy
fluorescent probe
cancer therapy
drug release
squamous cell carcinoma
radiation therapy
locally advanced
reactive oxygen species
electron transfer