Platelet-derived growth factor (PDGF)-BB regulates the airway tone via activation of MAP2K, thromboxane, actin polymerisation and Ca 2+ -sensitisation.
Annette Dorothea RiegSaid SuleimanCarolin AnkerNina A BüntingEva VerjansJan SpillnerSebastian KalverkampSaskia von StillfriedTill BraunschweigStefan UhligChristian MartinPublished in: Respiratory research (2022)
PDGFR regulates the airway tone. In PCLS from GPs, this regulatory mechanism depends on the β-subunit. Hence, PDGFR-inhibition may not only represent a target to improve chronic airway disease such as IPF, but may also provide acute bronchodilation in asthma. Since asthma therapy uses topical application. This is even more relevant, as nebulisation of imatinib also appears to be effective.
Keyphrases
- growth factor
- chronic obstructive pulmonary disease
- lung function
- liver failure
- allergic rhinitis
- idiopathic pulmonary fibrosis
- transcription factor
- respiratory failure
- protein kinase
- stem cells
- bone marrow
- vascular smooth muscle cells
- wound healing
- intensive care unit
- aortic dissection
- chronic myeloid leukemia
- air pollution
- angiotensin ii
- high density
- acute respiratory distress syndrome
- hepatitis b virus
- cell therapy