Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain.

Kai-Chun YangVladimir StepanovNahid AminiStefan MartinssonAkihiro TakanoJacob NielsenChristoffer BundgaardBenny Bang-AndersenSarah GrimwoodChrister HalldinLars FardeSjoerd J Finnema

Published in: European journal of nuclear medicine and molecular imaging (2016)

The method proposed for quantification of [11C]Lu AE92686 binding in applied studies in NHP is based on 63 min PET data and SRTM with cerebellum as a reference region. The study supports that [11C]Lu AE92686 can be used for PET examinations of PDE10A binding also in substantia nigra.

Keyphrases

pet ct
positron emission tomography
computed tomography
pet imaging
dna binding
electronic health record
machine learning
resting state
blood brain barrier