Late-stage construction of stapled peptides through Fujiwara-Moritani reaction between tryptophan and olefins.
Jiang LiuPeng WangWei ZengQi LuQing ZhuPublished in: Chemical communications (Cambridge, England) (2021)
Herein, the first example of a palladium-catalyzed Fujiwara-Moritani reaction for olefination of tryptophan (Trp) residues, free from directing groups, was presented. The developed reaction proceeds efficiently for peptide modification, ligation and peptide stapling.
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