Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion.

Ihab Abd-ElrahmanHisanori KosugeTommy Wises SadanYael Ben-NunKaren MeirChen RubinsteinMatthew BogyoMichael V McConnellGalia Blum

Published in: PloS one (2016)

Cathepsin ABPs present a rapid diagnostic tool for macrophage detection in atherosclerotic plaque. Our inhibitor confirms cathepsin-targeting as a promising approach to treat atherosclerotic plaque inflammation.

Keyphrases

loop mediated isothermal amplification
coronary artery disease
adipose tissue
oxidative stress
high resolution
fluorescence imaging
cardiovascular disease
small molecule
cancer therapy
stem cells
single molecule
type diabetes
sensitive detection
bone marrow
mass spectrometry