Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways.

Kristen R IbanezKaren N McFarlandJennifer PhillipsMariet AllenChristian B LessardLillian ZobelElsa Gonzalez De La CruzShivani ShahQuan VoXue WangZachary QuicksallDaniel RyuCory FunkNilüfer Ertekin-TanerStefan ProkopTodd E GoldeParamita Chakrabarty

Published in: Alzheimer's research & therapy (2022)

These data provide an important experimental framework for understanding the role of Abi3-Gngt2 function and early inflammatory gliosis in AD. Our studies also demonstrate that inflammatory gliosis could have opposing effects on amyloid and tau pathology, highlighting the unpredictability of targeting immune pathways in AD.

Keyphrases

cerebrospinal fluid
oxidative stress
multiple sclerosis
electronic health record
big data
data analysis