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Should a borderline negative HER2 result in a core biopsy of invasive carcinoma of the breast have HER2 assessment repeated in the excision specimen?

Andrew H S LeeZsolt HodiAreeg AbbasPeter WencykIan O EllisEmad A Rakha
Published in: Journal of clinical pathology (2023)
Repeat assessment yielded 4% 3+ results and 14% 2+ amplified carcinomas but with low level amplification. These results suggest that retesting of borderline negative HER2 cases should be optional and no longer mandatory.
Keyphrases
  • high grade
  • nucleic acid
  • clinical evaluation