Should a borderline negative HER2 result in a core biopsy of invasive carcinoma of the breast have HER2 assessment repeated in the excision specimen?
Andrew H S LeeZsolt HodiAreeg AbbasPeter WencykIan O EllisEmad A RakhaPublished in: Journal of clinical pathology (2023)
Repeat assessment yielded 4% 3+ results and 14% 2+ amplified carcinomas but with low level amplification. These results suggest that retesting of borderline negative HER2 cases should be optional and no longer mandatory.