Genome-wide association study of preserved ratio impaired spirometry (PRISm).
Daniel H HigbeeAlvin LirioFergus HamiltonRaquel GranellAnnah B WyssStephanie J LondonTraci M BartzSina A GharibMichael H ChoEmily S WanEdwin SilvermanJames D CrapoJesus V T LomincharTorben HansenNiels GrarupThomas DantoftLine KårhusAllan LinnebergGeorge T O'ConnorJosée DupuisHanfie XuMaaike M De VriesXiaowei HuStephen S RichR Graham BarrAni ManichaikulSara Renata Alex WijnantGuy G O BrusselleLies LahousseXuan LiAna I Hernández CorderoMa'en ObeidatDon D SinSarah E HarrisPaul RedmondAdele M TaylorSimon R CoxAlexander T WilliamsNick ShrineCatherine JohnAnna L GuyattIan P HallGeorge Davey SmithMartin D TobinJames William DoddPublished in: The European respiratory journal (2024)
), have not been described in association with lung function before, demonstrating the utility of using different lung function phenotypes in GWAS. Genetic factors associated with PRISm are strongly correlated with risk of both other lung diseases and extrapulmonary comorbidity.