Inhibition Effect of Pancreatic Exocrine Insufficiency on Immune Checkpoint Inhibitor Treatment in Pancreatic Cancer: A Retrospective Study.

Qiankun LuoYifei DongPan LiuChao HeLei ChenKailun ZhangChangjie PanYahui GaoTao Qin

Published in: ImmunoTargets and therapy (2024)

Immune checkpoint inhibitors (ICIs) increased the incidence of PEI in patients with PDAC. The OS was not different between patients receiving chemotherapy and ChIM due to irregular PERT treatment. The finding show that pancreatic enzyme replacement therapy may improve the response rate of patients with PDAC to ICIs.

Keyphrases

replacement therapy
squamous cell carcinoma
risk factors
combination therapy
locally advanced
rectal cancer