MULTIPLE NEUROENDOCRINE NEOPLASIA IN A PATIENT WITH TYPE I NEUROFIBROMATOSIS (NF1): REPORT OF A NEW MUTATION (NF1, EXONS 2-30 DELETION) AND LITERATURE REVIEW.

Victor Matheus Mendonça de Araújo Roberta Lais Mendonça de Mattos Lívia Guerreiro de Barros Bentes Rayama Moreira Siqueira Rita Barbosa de Carvalho Carlos Augusto Real Martinez

Published in: Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery (2023)

The co-occurrence of medullary thyroid carcinoma, plexiform neurofibromas, and neuroendocrine tumors of the rectum in patients with neurofibromatosis type 1 is an exceptional and undescribed possibility, whose diagnosis can be confirmed by the immunohistochemical staining and genetic panel.

Keyphrases

neuroendocrine tumors
signaling pathway
case report
lps induced
pi k akt
nuclear factor
oxidative stress
high grade
inflammatory response
toll like receptor
gene expression
flow cytometry