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Plasma HER2 (ERBB2) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer.

Giulia SiravegnaAndrea Sartore-BianchiRebecca J NagyKanwal RaghavJustin I OdegaardRichard B LanmanLivio TrusolinoSilvia MarsoniSalvatore SienaAlberto Bardelli
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
cfDNA is a viable alternative to tissue-based genotyping in the metastatic setting. The cfDNA platform utilized correctly identified 28 of 29 (96.6%) of pretreatment samples as ERBB2-amplified and predicted benefit from HER2-targeted therapy. In this study, an observed pCN of 2.4 and an adjusted pCN of 25.82 copies of ERBB2 are proposed to select patients who will benefit from HER2-targeted therapy.
Keyphrases
  • copy number
  • metastatic colorectal cancer
  • mitochondrial dna
  • tyrosine kinase
  • genome wide
  • high throughput
  • small cell lung cancer
  • dna methylation
  • gene expression