Both covalent organic frameworks (COFs) and polyoxometalates (POMs) show excellent properties and application potential in many fields, thus receiving widespread attention. In recent years, COF-POM hybrid materials were prepared by combining COFs and POMs through physical or chemical methods. COF-POM hybrids have shown high performance in many fields, such as catalysis, sensing, energy storage, and biomedicine. In this review, we introduced the preparation strategy and application of COF-POM hybrids in detail. We believe that the combination of COFs and POMs will provide more abundant functions and broad application prospects.