DNA damage and apoptosis induced by a potent orally podophyllotoxin derivative in breast cancer.

Yajie WangHua SunZhiyan XiaoGang ZhangDan ZhangXiuqi BaoFangfang LiShaoyu WuYuanchao GaoNing Wei

Published in: Cell communication and signaling : CCS (2018)

XWL-1-48 may be a promising orally topoII inhibitor, its mechanisms are associated with suppression of TopoII, induction of DNA damage and apoptosis, blockage of PI3K/AKT/Mdm2 pathway.

Keyphrases

cell cycle arrest
dna damage
pi k akt
oxidative stress
cell death
signaling pathway
dna repair
cell proliferation
endoplasmic reticulum stress
anti inflammatory
young adults