Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy.
Christina KoberJulian RoeweNorbert SchmeesLars RoeseUlrike RoehnBenjamin BaderDetlef StoeckigtFlorian PrinzMátyás GorjánáczHelge Gottfried RoiderCatherine OleschGabriele LederHorst IrlbacherRalf LescheJulien LefrancMine Oezcan-WahlbrinkAnkita Sati BatraNirmeen ElmadanyRafael CarreteroKatharina SahmIris OezenFrederik CichonDaniel BaumannAhmed SadikChristiane A OpitzHilmar WeinmannIngo V HartungBertolt KreftRienk OffringaMichael PlattenIlona GutcherPublished in: Journal for immunotherapy of cancer (2023)
These findings identify AhR inhibition as a novel therapeutic approach to overcome immune resistance in various types of cancers.