A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome.
Maria Francesca EvaristiBruno PoirierXavier ChénedéAnne-Marie LefebvreAlain RocconFlorence GillotSandra BeeskéAlain CorbierMarie-Pierre Pruniaux-HarnistPhilip JaniakAshfaq A ParkarPublished in: PloS one (2022)
These experimental findings suggest that S1P1 activation with SAR247799 may be considered as a new therapeutic approach for LVH and diastolic dysfunction, major components of HFpEF.