Transient receptor potential a1 (TRPA1) agonists inhibit contractions of the isolated human ureter.

Philipp WeinholdMartin HennenbergFrank StrittmatterChristian G StiefChristian GratzkePetter Hedlund

Published in: Neurourology and urodynamics (2017)

In the human ureter, TRPA1 is located to sensory nerves and interstitial cells. TRPA1 agonists inhibited electrically induced contractions but had no direct effect on smooth muscle tension of the human ureter. A role for TRPA1 in modulating neurotransmission and possibly peristalsis of the human ureter is proposed.

Keyphrases

endothelial cells
smooth muscle
induced pluripotent stem cells
risk assessment
signaling pathway
urinary tract
oxidative stress
brain injury
cell proliferation
endoplasmic reticulum stress
binding protein
cell cycle arrest