Cu-Catalyzed Cross-Dehydrogenative ortho-Aminomethylation of Phenols.

Published in: Angewandte Chemie (International ed. in English) (2018)

A highly selective CuII -catalyzed cross-dehydrogenative ortho-aminomethylation of phenols with aniline derivatives is described. The corresponding C(sp2 )-C(sp3 ) coupling products were obtained in moderate to excellent yields under mild reaction conditions and with a broad substrate scope. A radical mechanism is proposed.

Keyphrases

room temperature
high intensity
electron transfer
structural basis
structure activity relationship