Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism.

Claudio Peter D'Incal Kirsten Esther Van RossemKevin De ManAnthony KoningsAnke Van DijckLudovico RizzutiAlessandro VitrioloGiuseppe TestaIllana GozesWim Vanden Berghe R Frank Kooy

Published in: Clinical epigenetics (2023)

We here present an integrated evaluation of all current aspects of gene function and evaluate how abnormalities in chromatin remodeling might relate to the pleiotropic clinical presentation in individual"s" with Helsmoortel-Van der Aa syndrome.

Keyphrases

genome wide
intellectual disability
dna damage
gene expression
transcription factor
autism spectrum disorder
dna methylation
copy number
genome wide identification
binding protein
oxidative stress
small molecule
blood brain barrier