Unique clinical and autoantibody profile of a large Asian Indian cohort of scleroderma-do South Asians have a more aggressive disease?
Ramya JanardanaAswin M NairAjit K SurinJohn Anthony Jude PrakashMahasampath GowriDebashish DandaPublished in: Clinical rheumatology (2019)
• Asian Indian scleroderma patients are younger by 2 decades compared to Caucasian series. • Higher prevalence of Scl-70 antibody, its association with young age, interstitial lung disease and pulmonary hypertension are features of our cohort. • High prevalence of interstitial lung disease (88.1%) was noted ; among those with baseline spirometry data (141/327), two thirds(66%) had moderate to severe restriction. • Younger age at onset, higher prevalence of Scl-70 antibody are features common to other Indian, Thai and Chinese series.
Keyphrases
- interstitial lung disease
- systemic sclerosis
- rheumatoid arthritis
- idiopathic pulmonary fibrosis
- pulmonary hypertension
- end stage renal disease
- risk factors
- newly diagnosed
- ejection fraction
- peritoneal dialysis
- prognostic factors
- high intensity
- early onset
- chronic obstructive pulmonary disease
- pulmonary arterial hypertension
- pulmonary artery
- african american
- patient reported outcomes
- deep learning
- data analysis
- artificial intelligence