miR-146a-5p impairs melanoma resistance to kinase inhibitors by targeting COX2 and regulating NFkB-mediated inflammatory mediators.

Elisabetta VerganiMatteo DugoMara CossaSimona FrigerioLorenza Di GuardoGianfrancesco GallinoIlaria MattavelliBarbara VerganiLuca LalliElena TamboriniBarbara ValeriChiara GargiuliEriomina ShahajMarina FerrariniElisabetta FerreroMacarena Gomez LiraVeronica HuberMichele Del VecchioMarialuisa SensiBiagio Eugenio LeoneMario SantinamiLicia RivoltiniMonica RodolfoViviana Vallacchi

Published in: Cell communication and signaling : CCS (2020)

Deregulation of the miR-146a-5p/COX2 axis occurs in the development of melanoma resistance to targeted drugs in melanoma patients. This finding reveals novel targets for more effective combination treatment. Video Abstract.

Keyphrases

end stage renal disease
chronic kidney disease
skin cancer
ejection fraction
peritoneal dialysis
prognostic factors
oxidative stress
basal cell carcinoma
cancer therapy
patient reported outcomes
drug delivery
combination therapy
smoking cessation