Secretion of miRNA-326-3p by senescent adipose exacerbates myocardial metabolism in diabetic mice.

Hao LinXiaonan ChenJianan PanJiahan KeAlian ZhangYangyang LiuChangqian WangAlex Chia Yu ChangJun Gu

Published in: Journal of translational medicine (2022)

We demonstrate for the first time that senescent adipose derived LEVs exacerbates myocardial metabolism through up-regulated miRNA-326-3p which inhibits Rictor in cardiomyocytes. Furthermore, reducing senescence burden in adipose tissue is capable of relieving myocardial metabolism disorder in diabetes mellitus.

Keyphrases

adipose tissue
left ventricular
insulin resistance
dna damage
endothelial cells
high fat diet
heart failure
transcription factor
risk factors
stress induced
oxidative stress
weight loss