Temperature-driven coordination of circadian transcriptome regulation.

subjected to low temperatures, little is known regarding how these changes are enacted at a molecular level. By conducting bulk RNA sequencing from fruit flies, we observe that genome-wide circadian oscillation patterns are temperature dependent. Intriguingly, we find that morning and evening peaks of transcriptomic activity shift closer together, consistent with anticipation of a shorter photoperiod in cooler winter weather. We further find that the low-temperature dynamics are highly coordinated with respect to a reference-based gene regulatory network. Our findings provide insights into the mechanisms by which flies adapt to environmental temperature changes.