Fragilides K and L, New Briaranes from the Gorgonian Coral Junceella fragilis.
Li-Guo ZhengYu-Chia ChangChiung-Chih HuZhi-Hong WenYang-Chang WuPing-Jyun SungPublished in: Molecules (Basel, Switzerland) (2018)
Two new briarane metabolites—fragilides K (1) and L (2)—along with five known analogues—gemmacolide X, praelolide, juncins P and ZI, and gemmacolide V (3⁻7)—were extracted and purified from Junceella fragilis, a gorgonian coral. Based on data obtained via spectroscopic techniques, the structures of new briaranes 1 and 2 were determined and the cyclohexane rings in 1 and 2 were found to exist in chair and twist boat conformation, respectively. Additionally, anti-inflammatory analysis showed that briaranes 2, 3, and 6 inhibited pro-inflammatory inducible nitric oxide synthase protein expression and briaranes 3 and 7 suppressed the cyclooxygenase-2 level, in LPS-stimulated murine macrophage-like RAW264.7 cells.
Keyphrases
- nitric oxide synthase
- anti inflammatory
- nitric oxide
- molecular docking
- induced apoptosis
- cell cycle arrest
- inflammatory response
- molecular dynamics simulations
- ms ms
- high resolution
- big data
- oxidative stress
- cell proliferation
- mass spectrometry
- endoplasmic reticulum stress
- machine learning
- data analysis
- cell death
- structure activity relationship