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Targeted Protein Degradation Technology and Nanomedicine: Powerful Allies against Cancer.

Jia-Yi LinHai-Jun LiuYe WuJin-Mei JinYu-Dong ZhouHong ZhangDale G NagleHong-Zhuan ChenWei-Dong ZhangXin Luan
Published in: Small (Weinheim an der Bergstrasse, Germany) (2023)
Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential of targeting undruggable pathogenic proteins. After the first proof-of-concept proteolysis-targeting chimeric (PROTAC) molecule was reported, the TPD field has entered a new era. In addition to PROTAC, numerous novel TPD strategies have emerged to expand the degradation landscape. However, their physicochemical properties and uncontrolled off-target side effects have limited their therapeutic efficacy, raising concerns regarding TPD delivery system. The combination of TPD and nanotechnology offers great promise in improving safety and therapeutic efficacy. This review provides an overview of novel TPD technologies, discusses their clinical applications, and highlights the trends and perspectives in TPD nanomedicine.
Keyphrases
  • cancer therapy
  • drug delivery
  • cell therapy
  • stem cells
  • squamous cell carcinoma
  • amino acid
  • single cell
  • risk assessment
  • young adults
  • mesenchymal stem cells
  • bone marrow