Firing activity of locus coeruleus noradrenergic neurons decreases in necdin-deficient mice, an animal model of Prader-Willi syndrome.
Rui-Ni WuWei-Chen HungChing-Tsuey ChenLi-Ping TsaiWen-Sung LaiMing-Yuan MinShi-Bing WongPublished in: Journal of neurodevelopmental disorders (2020)
LC-NE neuronal firing activity decreased in necdin-deficient mice, suggesting that LC, the primary source of norepinephrine in the central nervous system, is possibly involved in PWS pathogenesis.