Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer's disease.

Shuaipeng MaTong ZangMeng-Lu LiuChun-Li Zhang

Published in: Molecular neurodegeneration (2020)

Aging-relevant BFCNs can be directly reprogrammed from human skin fibroblasts of healthy adults and sporadic AD patients. They show promises as an aging-relevant cell model for understanding AD pathology and may be employed for therapeutics identification for AD.

Keyphrases

end stage renal disease
single cell
cell therapy
endothelial cells
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
late onset
spinal cord
spinal cord injury
bone marrow
mild cognitive impairment