Primary adjunctive corticosteroid therapy is associated with improved outcomes for patients with Kawasaki disease with coronary artery aneurysms at diagnosis.
Kevin G FriedmanKimberlee GauvreauAnnette BakerMary Beth SonRobert SundelAudrey DionneThomas GiorgioSarah De FerrantiJane W NewburgerPublished in: Archives of disease in childhood (2020)
Primary adjunctive corticosteroid therapy is associated with decreased initial treatment resistance, greater improvement in inflammatory markers and higher likelihood of CAA regression in patients who have CAA at diagnosis. Multi-centre, randomised controlled trials are needed to confirm the benefits of corticosteroids in patients with CAA at diagnosis and to compare corticosteroids with other adjunctive therapies.
Keyphrases
- coronary artery
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- pulmonary artery
- prognostic factors
- peritoneal dialysis
- type diabetes
- adipose tissue
- metabolic syndrome
- skeletal muscle
- mesenchymal stem cells
- replacement therapy
- bone marrow
- pulmonary arterial hypertension
- patient reported