A Study to Evaluate the Effectiveness and Safety of Prephase Steroid Treatment before Remission Induction Chemotherapy in Patients with Pediatric Acute Lymphoblastic Leukemia Using Common Data Model-Based Real-World Data: A Retrospective Observational Study.
Yoona ChoiBo Kyung KimJung-Hyun WonJae Won YooWona ChoiSurin JungJae Yoon KimIn Young ChoiNack-Gyun ChungJae Wook LeeJung Yoon ChoiHyoung Jin KangHoward LeePublished in: Clinical epidemiology (2024)
Prephase steroid treatment for ≥7 days before RIC in pediatric patients with ALL reduces the risk of TLS, while careful monitoring for toxicities is necessary. If adequately analyzed, real-world data can provide crucial effectiveness and safety information for proper management of pediatric patients with ALL, for whom prospective randomized studies may be difficult to perform for ethical and practical reasons.