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Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α.

Jiali ZhaoEn LinChaonong CaiManyao ZhangDecheng LiShanglin CaiGuifang ZengZeren YinBo WangPeiping LiXiaopeng HongJiafan ChenBaojia ZouJian Li
Published in: Drug design, development and therapy (2022)
Our results suggested that Tan I could effectively improve the anti-tumor effect of EADM, and synergize EADM to reverse HIF-1α mediated resistance via targeting PI3K/AKT/HIF-1α signaling pathway.
Keyphrases
  • pi k akt
  • signaling pathway
  • cell cycle arrest
  • cell proliferation
  • endothelial cells
  • induced apoptosis
  • epithelial mesenchymal transition
  • cancer therapy
  • single cell
  • oxidative stress
  • cell death