Circulating plasma proteins and new-onset diabetes in a population-based study: proteomic and genomic insights from the STANISLAS cohort.

Joao Pedro FerreiraZohra LamiralConstance XhaardKévin DuarteEmmanuel BressoMarie-Dominique DevignesEdith Le FlochClaire Dandine RoullandJean-François DeleuzeSandra WagnerBruno GuerciNicolas GirerdFaiez ZannadJean-Marc BoivinPatrick Rossignol

Published in: European journal of endocrinology (2020)

The risk of developing pre-diabetes and T2D increases with age and with features of the metabolic syndrome. Circulating PAPP-A, which has an important genetic component, was associated with both the development and presence of pre-diabetes and T2D.

Keyphrases

type diabetes
cardiovascular disease
metabolic syndrome
glycemic control
copy number
insulin resistance
genome wide
gene expression
uric acid
adipose tissue
label free
weight loss