Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier.
Lisa B FridmanStephen KnerlerAmira-Storm PriceRodnie Colón OrtizAlicia MercadoHannah WilkinsBianca R FloresBenjamin C OrsburnDionna W WilliamsPublished in: bioRxiv : the preprint server for biology (2023)
Our findings indicate that additional considerations are needed in CNS HIV treatment strategies for people who use cocaine, as it may limit ART efficacy through regulation of drug transport and metabolizing pathways at the BBB.