CD103+ tumor-resident CD8+ T cell numbers underlie improved patient survival in oropharyngeal squamous cell carcinoma.

Rehana HewavisentiAngela FergusonKevin WangDeanna JonesThomas GebhardtJarem EdwardsMei ZhangWarwick BrittonJean YangAngela HongUmaimainthan Palendira

Published in: Journal for immunotherapy of cancer (2021)

Our results show that CD103+ tumor-resident CD8+ T cells are critical for protective immunity in both types of OPSCCs. Our data further suggest that the enhanced local protective immunity provided by tumor-resident T cell responses is the underlying factor driving favorable clinical outcomes in HPV+ OPSCCs over HPV- OPSCCs.

Keyphrases

squamous cell carcinoma
patient safety
quality improvement
high grade
machine learning
lymph node metastasis
locally advanced
cervical cancer screening