Cluster analysis for the identification of clinical phenotypes among antiphospholipid antibody-positive patients from the APS ACTION Registry.
Stéphane ZuilyIsabelle Clerc-UrmèsCédric BaumanDanieli AndradeSavinio SciasciaVittorio PengoMaria G G TektonidouAmaia UgarteMaria GerosaH Michael BelmontMaria Angeles Aguirre ZamoranoPaul FortinLanlan JiMaria EfthymiouHannah CohenDavid Ware BranchGuilherme Ramires de JesusCecilia NalliMichelle A PetriEsther RodriguezRicard CerveraJason S KnightTatsuya AtsumiRohan WillisMaria Laura BertolacciniJoann VegaDenis WahlDoruk Erkannull nullPublished in: Lupus (2020)
Based on our hierarchical cluster analysis, we identified different clinical phenotypes of aPL-positive patients discriminated by aPL profile, lupus or CVD risk factors. Our results, while supporting the heterogeneity of aPL-positive patients, also provide a foundation to understand disease mechanisms, create new approaches for APS classification and ultimately develop new management approaches.