Multiple Myeloma: Case of a "Moving" Sternal Wire.
Yun Song ChooMelissa Gaik-Ming OoiShi WangJames Thomas Patrick Decourcy HallinanPublished in: Diagnostics (Basel, Switzerland) (2023)
Multiple myeloma generally occurs in older adults, with the clonal proliferation of plasma cells and accumulation of monoclonal protein resulting in a broad range of clinical manifestations and complications, including hypercalcemia, renal dysfunction, anaemia, and bone destruction (termed CRAB features). A 64-year-old man with no history of malignancy presented with an enlarging precordial lump occurring three years post-sternotomy for uneventful coronary artery bypass grafting surgery. Initial investigations showed anaemia and impaired renal function. Multimodal imaging performed for further evaluation showcases the radio-pathological features which can be encountered in haematological malignancy. Subsequent percutaneous biopsy confirmed an underlying plasma cell neoplasm, and a diagnosis of multiple myeloma was achieved. The prompt resolution of the lesions upon the initiation of treatment highlights the importance of early diagnosis and treatment.
Keyphrases
- multiple myeloma
- coronary artery bypass grafting
- minimally invasive
- coronary artery disease
- percutaneous coronary intervention
- induced apoptosis
- ultrasound guided
- high resolution
- signaling pathway
- oxidative stress
- cell cycle arrest
- single cell
- bone mineral density
- iron deficiency
- physical activity
- stem cells
- risk factors
- pain management
- cell death
- aortic valve replacement
- single molecule
- fine needle aspiration
- community dwelling
- postmenopausal women
- radiofrequency ablation
- small molecule
- binding protein
- bone marrow
- endoplasmic reticulum stress
- soft tissue
- high grade
- bone regeneration