Episodic replacement of clotting factor concentrates does not prevent bleeding or musculoskeletal damage - the MUSFIH study.
Pradeep Mathew PoonnooseJ D A CarneiroA L CruickshankM El EkiabyR P Perez BiancoMargareth Castro OzeloN De BoschM BaghaipourS L TienAmpaiwan ChuansumritE A D'AmicoA van ZylA SabourM CandelaJ B S RicciardiA Ruiz-SàezR RavanbodJ C L LamS JaovisidhaM L KavithaS GibikoteN ShyamkumarAlok Srivastavanull nullPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2017)
Episodic CFC replacement over a large range of doses does not alter the natural course of bleeding in haemophilia or the musculoskeletal deterioration and should not be recommended as a long term option for treatment. Prophylaxis is the only way to preserve musculoskeletal function in haemophilia.