The role of the gluteofemoral adipose tissue in cerebrovascular disease risk: evidence from a mendelian randomization and mediation analysis.

Evangelos Pavlos MyserlisMarios K GeorgakisLivia ParodiErnst MayerhoferJonathan RosandChirantan BanerjeeChristopher D Anderson

Published in: medRxiv : the preprint server for health sciences (2024)

Genetically proxied, BMI-independent higher GFAT volume is associated with reduced cerebrovascular disease risk. Although this is largely mediated by common vascular risk factor modification, targeting adipose-tissue specific pathways may provide additional cardiovascular benefit.

Keyphrases

adipose tissue
insulin resistance
risk factors
body mass index
high fat diet
type diabetes
metabolic syndrome
physical activity
drug delivery
weight gain
weight loss