Nortropane alkaloids as pharmacological chaperones in the rescue of equine adipose-derived mesenchymal stromal stem cells affected by metabolic syndrome through mitochondrial potentiation, endoplasmic reticulum stress mitigation and insulin resistance alleviation.
Lynda BourebabaFatiha BedjouMichael RöckenKrzysztof MaryczPublished in: Stem cell research & therapy (2019)
Obtained data open new perspectives in the development of new drugs, which may improve the metabolic dynamics of cells challenged by MS.
Keyphrases
- induced apoptosis
- endoplasmic reticulum stress
- stem cells
- insulin resistance
- metabolic syndrome
- oxidative stress
- bone marrow
- signaling pathway
- adipose tissue
- mass spectrometry
- minimally invasive
- type diabetes
- multiple sclerosis
- electronic health record
- climate change
- polycystic ovary syndrome
- high fat diet
- ms ms
- skeletal muscle
- heat shock
- machine learning
- cardiovascular risk factors
- cell death
- cardiovascular disease
- cell proliferation
- heat stress
- heat shock protein