Highly Oxidized Ecdysteroids from a Commercial Cyanotis arachnoidea Root Extract as Potent Blood-Brain Barrier Protective Agents.
Gábor TóthAna R Santa-MariaIbolya HerkeTamás GátiDaniel Galvis-MontesFruzsina R WalterMária A DeliAttila HunyadiPublished in: Journal of natural products (2023)
Ecdysteroid-containing herbal extracts, commonly prepared from the roots of Cyanotis arachnoidea , are marketed worldwide as a "green" anabolic food supplement. Herein are reported the isolation and complete 1 H and 13 C NMR signal assignments of three new minor ecdysteroids (compounds 2 - 4 ) from this extract. Compound 4 was identified as a possible artifact that gradually forms through the autoxidation of calonysterone. The compounds tested demonstrated a significant protective effect on the blood-brain barrier endothelial cells against oxidative stress or inflammation at a concentration of 1 μM. Based on these results, minor ecdysteroids present in food supplements may offer health benefits in various neurodegenerative disease states.
Keyphrases
- oxidative stress
- blood brain barrier
- endothelial cells
- human health
- diabetic rats
- dna damage
- ischemia reperfusion injury
- public health
- induced apoptosis
- cerebral ischemia
- healthcare
- magnetic resonance
- mental health
- high resolution
- health information
- risk assessment
- anti inflammatory
- high glucose
- image quality
- low density lipoprotein
- solid state
- subarachnoid hemorrhage