Login / Signup

Managing complications of chronic pancreatitis: a guide for the gastroenterologist.

Gabriele CapursoMatteo TacelliGiuseppe VanellaRuggero Ponz de Leon PisaniGiuseppe Dell'annaMartina AbatiRoberto MeleGaetano LauriAfrodita PanaitescuRubino NunziataPiera ZaccariLivia ArchibugiPaolo Giorgio Arcidiacono
Published in: Expert review of gastroenterology & hepatology (2023)
At diagnosis and during chronic pancreatitis follow-up, particular care is needed to consider not only the clinically manifest signs and symptoms of the disease, such as pain, jaundice, gastrointestinal obstruction, and pseudocysts, which require multidisciplinary discussion to establish the best treatment option (endoscopic or surgical), but also less evident systemic complications. Pancreatic exocrine and endocrine insufficiency, together with chronic inflammation, addiction, and dysbiosis, contribute to malnutrition, sarcopenia, and osteopathy. These complications, in turn, increase the risk of infection, thromboembolic events, and death. Patients with chronic pancreatitis also have an increased risk of psychiatric disorders and pancreatic cancer onset. Overall, patients with chronic pancreatitis should receive a holistic evaluation, considering all these aspects, possibly through multidisciplinary care in dedicated expert centers.
Keyphrases