A cubic DNA nanocage probe for in situ analysis of miRNA-10b in tumor-derived extracellular vesicles.

Xiaoyan SunYafei ChenHaiyan LiWei XingMing-Li Chen Jian-Hua Wang Lei Ye

Published in: Chemical communications (Cambridge, England) (2024)

A cubic DNA nanocage probe is able to enter EVs derived from MDA-MB-231 cells and react with miRNA-10b. The probe-loaded EVs were employed to monitor the process of entry of miRNA-10b into MCF-10A cells, allowing visualization of EV-mediated intercellular communication of miRNA-10b between the cancer cells.

Keyphrases

induced apoptosis
cell cycle arrest
living cells
quantum dots
circulating tumor
single molecule
cell free
breast cancer cells
endoplasmic reticulum stress
cell death
drug delivery
oxidative stress
cancer therapy
fluorescent probe
circulating tumor cells
wound healing