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An Approach to Functionally Embellished o -Alkynylbenzoates or Furan-3(2 H )-ones from Diynones and DMAD: Controlled Divergence and Product Selectivity.

Manas Jyoti SarmaK A SudarshanaPabbaraja SrihariGoverdhan Mehta
Published in: The Journal of organic chemistry (2023)
The discovery of reaction regime controlled product diversification in a one-pot reaction between diynones and dimethyl-1,3-acetonedicarboxylate (DMAD) to selectively furnish either functionally unique pentasubstituted o -alkynylbenzoates or fully substituted furan-3(2 H )-ones is delineated. The potential of these two versatile platforms to enter new utilitarian chemical space has also been explored.
Keyphrases
  • small molecule
  • molecular docking
  • high throughput
  • electron transfer
  • human health
  • climate change
  • structural basis